研峰科技 Infinity Scientific

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4-Aminoantipyrine 4-氨基安替吡啉

規格: 98%

CAS: 83-07-8

產品編號: H24967

MDL: MFCD00003145

品牌: INFI

Chemical Name	4-Aminoantipyrine
CAS Number	83-07-8
Synonym	######## 1,5-二甲基-2-苯基-4-氨基-3-吡唑啉酮 1-PHENYL-2,3-DIMETHYL-4-AMINO-3-PYRAZOLIN-5-ON 3-Pyrazolin-5-one, 4-amino-2,3-dimethyl-1-phenyl- 4 Amino 1,5 Dimethyl 2 Phenyl 3H Pyrazolone 4 Aminoantipyrine 4 Aminophenazone 4-AMINO-1,3-DIMETHYL-2-PHENYL-3-PYRAZOLONE 4-AMINO-1,5-DIMETHYL-2-PHENYL-1,2-DIHYDRO-PYRAZOL-3-ONE 4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLINE-5-ONE 4-AMINOANTIPYRINE 4-AMINOPHENAZONE 4-Amino-1,5-Dimethyl-2-Phenyl-3H-Pyrazolone 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one 4-Aminoantipyrine 4-Aminophenazone 4-Amminoantipirina 4-氨基-1,2-二氫-1,5-二甲基-2-苯基-3H-吡唑-3-酮 4-氨基-1,5-二甲基-2-苯基-3-吡唑啉酮 4-氨基安替吡啉 4-氨基安替比林 4-氨基安替比林；4-氨基非那宗；4-氨基-1,5-二甲基-2-苯基-3-吡唑啉酮 4-氨基非那宗 4-胺-1,5-二甲-2-苯-3H-吡唑-3-酮
PubChem Substance ID	87561316
EC Number	201-452-3
Beilstein Registry Number	181635
MDL Number	MFCD00003145
Reaxys-RN	181635
Merck Number	591
Chemical Name Translation	4-氨基安替比林
Wiswesser Line Notation	T5NNVJ A1 BR& DZ E1
LabNetwork Molecule ID	LN00193860
InChI	InChI=1S/C11H13N3O/c1-8-10(12)11(15)14(13(8)2)9-6-4-3-5-7-9/h3-7H,12H2,1-2H3

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   117,638,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 270 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 10,820,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 99,171,1950

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 47,636,1982

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 312 ug/well
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 133,161,1984

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 umol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 206,317,1988

WGK Germany	3
Hazard Codes	Xn
Hazard statements
H302 Harmful if swallowed 吞食有害 H315 Causes skin irritation 會刺激皮膚 H319 Causes serious eye irritation 嚴重刺激眼睛 H335 May cause respiratory irritation 可能導致呼吸道刺激
Personal Protective Equipment	dust mask type N95 (US), Eyeshields, Gloves
RTECS	CD2480000
Precautionary statements
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉塵/煙/氣體/煙霧/蒸汽/噴霧。 P264 Wash hands thoroughly after handling. 處理后要徹底洗凈雙手。 P270 Do not eat, drink or smoke when using this product. 使用本產品時不要吃東西，喝水或吸煙。 P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通風良好的地方使用。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防護手套/防護服/眼睛的保護物/面部保護物。 P301+P312 P301+P312+P330 P302+P352 P302+P352+P332+P313+P362+P364 P304+P340 P305+P351+P338 P305+P351+P338+P337+P313 P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感覺不適，呼叫解毒中心或醫生/醫師。 P321 Specific treatment (see … on this label). 具體治療（見本標簽上的）。 P330 Rinse mouth. 漱口 P332+P313 P337+P313 P362 Take off contaminated clothing and wash before reuse. 脫掉污染的衣服，清洗后方可重新使用 P403+P233 P405 Store locked up. 上鎖保管。 P501 Dispose of contents/container to..… 處理內容物/容器.....
Signal word	Warning
Safety Statements
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接觸后，立即用大量水沖洗并征求醫生意見； S36 Wear suitable protective clothing 穿戴適當的防護服； S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴適當的防護服、手套和眼睛/面保護；
Risk Statements
R22 Harmful if swallowed 吞咽有害 R36/37/38 Irritating to eyes, respiratory system and skin 對眼睛、呼吸系統和皮膚有刺激性
Storage condition	密封陰涼保存。 Store at RT. 密封陰涼避光保存。

A reagent for glucose determination in the presence of peroxidase and phenol

{TRC} Alhadeff, E., et al.: App. Biochem. Biotechnol., 146, 129 (2008),

{SA} Merck 14 ,591

{ALD} Merck: 14,591

{ALD} Merck: 14,591

Beilstein: 25,IV,3554

{MCE} [1]. Berno CR, et al. 4-Aminoantipyrine reduces toxic and genotoxic effects of doxorubicin, cisplatin, and cyclophosphamide in male mice. Mutat Res Genet Toxicol Environ Mutagen. 2016 Jul;805:19-24.

83-07-8 H24967 4-Aminoantipyrine
4-氨基安替吡啉

化學屬性

Mol. Formula	C11H13N3O
Mol. Weight	203
Melting Point	105-110
Density	0.800
TSCA	Yes
Solubility	Soluble in water (50 mg/ml).
Stability	對光、濕度和空氣敏感

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