| Chemical Name | Potassium bis(trimethylsilyl)amide |
|---|
| Synonym |
六甲基二硅氮烷 鉀鹽 溶液
雙(三甲基硅基)氨基鉀, 20% W/W, 0.91M IN THF
雙(三甲基硅烷基)氨基鉀 溶液
Potassium hexamethyldisilazide
六甲基二硅基胺基鉀 溶液
六甲基二硅基胺基鉀 溶液 六甲基二硅氮烷 鉀鹽 溶液 |
| MDL Number | MFCD00010330 |
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| PubChem Substance ID | 3251421 |
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| Beilstein Registry Number | 4006754 |
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| EC Number | 424-100-2 |
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| CAS Number | 40949-94-8 |
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| Alfabeta Name | POTASSIUMBISTRIMETHYLSILYLAMIDE () |
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| Chemical Name Translation | 雙(三甲基硅基)氨基鉀 |
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| Reaxys-RN | 4006754 |
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| LabNetwork Molecule ID | LN00163929 |
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| InChI | InChI=1S/C6H18NSi2.K/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1 |
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| InChIKey | IUBQJLUDMLPAGT-UHFFFAOYSA-N |
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| WGK Germany | 3 |
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GHS Symbol
| Precautionary statements | |
|---|
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通風良好的地方使用。
- P501 Dispose of contents/container to..… 處理內容物/容器.....
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 遠離熱源/火花/明火/熱的表面?！刮鼰?。
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或醫生/醫師。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉塵/煙/氣體/煙霧/蒸汽/噴霧。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防護手套/防護服/眼睛的保護物/面部保護物。
- P305+P351+P338
- P403+P233
- P305+P351+P338+P310
- P264 Wash hands thoroughly after handling. 處理后要徹底洗凈雙手。
- P301+P330+P331+P310
- P201 Obtain special instructions before use. 使用前獲取專門指示。
- P240 Ground/bond container and receiving equipment. 與地面接觸/連接集裝箱和接受設備。
- P370+P378
- P304+P340
- P270 Do not eat, drink or smoke when using this product. 使用本產品時不要吃東西，喝水或吸煙。
- P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆電氣/通風/照明/ .../設備。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉塵/煙/氣體/煙霧/蒸汽/噴霧。
- P202 Do not handle until all safety precautions have been read and understood. 已閱讀并理解所有的安全預防措施之前，切勿操作。
- P301+P310
- P301+P310+P331
- P273 Avoid release to the environment. 避免釋放到環境中。
- P308+P311
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| Hazard statements | |
|---|
- H314 Causes severe skin burns and eye damage 導致嚴重的皮膚灼傷和眼睛損傷
- H225 Highly flammable liquid and vapour 高度易燃液體和蒸氣
- H302 Harmful if swallowed 吞食有害
- H351 Suspected of causing cancer 懷疑致癌
- H335 May cause respiratory irritation 可能導致呼吸道刺激
- H304 May be fatal if swallowed and enters airways 吞食和進入呼吸道可能致命
- H336 May cause drowsiness or dizziness 肯能導致嗜睡或頭暈
- H361d Suspected of damaging the unborn child 懷疑對未出生嬰兒造成傷害
- H373 May causes damage to organs through prolonged or repeated exposure 長期或頻繁接觸可能會損傷器官
|
| Personal Protective Equipment |
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
| Signal word |
|
| Packing Group | II |
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| UN Number |
UN2924 |
| Risk Statements | |
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- R14 Reacts violently with water 遇水會猛烈反應
- R11 Highly flammable 非常易燃
- R63 Possible risk of harm to the unborn child 可能危害未出生嬰兒
- R48/20
- R67 Vapours may cause drowsiness and dizziness 蒸汽可能導致嗜睡和昏厥
- R65 Harmful: may cause lung damage if swallowed 若吞咽可能傷害肺部器官
- R34 Causes burns 會導致灼傷
- R19 May form explosive peroxides 可能生成易爆的過氧化物質
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| Safety Statements | |
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- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 發生事故時或感覺不適時，立即求醫（可能時出示標簽）；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接觸后，立即用大量水沖洗并征求醫生意見；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴適當的防護服、手套和眼睛/面保護；
- S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 著火時使用（指明具體的消防器材種類，如果用水增加危險，注明“禁止用水”
- S30 Never add water to this product 切勿將水加入該產品中；
- S20 When using do not eat or drink 使用時，不得進食，飲水；
- S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入氣體/煙霧/蒸汽/噴霧；
- S33 Take precautionary measures against static discharges 對靜電采取預防措施；
- S16 Keep away from sources of ignition - No smoking 遠離火源，禁止吸煙；
- S60 This material and its container must be disposed of as hazardous waste 該物質及其容器必須作為危險廢物處置；
- S9 Keep container in a well-ventilated place 保持容器在通風良好的場所；
- S8 Keep container dry 保持容器干燥；
|
| Storage condition |
Refrigerator
Air & Moisture Sensitive
充氬保存 |
| Warnings |
IRRITANT |
| Hazard Codes |
F,C |
| Hazard Class | 3/8 |
|---|
| Restrict |
- |
⑴.常溫常壓條件下為液體。
⑵.非親核性強堿。
⑶.醫藥中間體，主要用于合成頭孢抗生素的生產。
非親核性強堿。
{ALF} Also used in the Wittig reaction, to give Li salt-free product distribution for selective (Z)-alkene formation: J. Org. Chem., 45, 4260 (1980). Has also been used with 18-crown-6 for selective formation of (Z)-ɑß-unsaturated esters from phosphonates: Tetrahedron Lett., 24, 4405 (1983).
{ALF} Sterically hindered strong base, compare Sodium bis(trimethyl­silyl)­amide, L13352 and Lithium bis(trimethyl­silyl)­amide, L15012. Used in the generation of K enolates, preferred to their Li or Na counterparts in some reactions, see e.g.: Tetrahedron Lett., 32, 1779 (1991); J. Am. Chem. Soc., 109, 6881 (1987); 111, 1063 (1989).
